Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)

CATEGORIES: General SLE

First filed August, 2019, updated January, 2021
CATEGORIES: General SLE

This phase 2b, multi-center, double-blind, randomized, placebo-controlled, 52-week, dose-ranging study is investigating AMG 570 in subjects with active SLE who have had inadequate response to SOC therapies including oral corticosteroids (OCS), immunosuppressants and immunomodulators.

This study is being offered at 24 LuCIN sites – institutions that are members of the Lupus Clinical Investigators Network managed by Lupus Therapeutics, an affiliate of the Lupus Research Alliance.

To Learn More Contact
Click Here to Visit AmgenTrials
Clinicaltrials.gov Identifier: NCT04058028

24 LuCIN sites (U.S. and Canada)

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

CATEGORIES: General SLE

First filed March 2020, Updated January 2021; Recruiting
CATEGORIES: General SLE

The purpose of this Phase 3 study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinically relevant long term improvement of moderate to severe disease activity.

This study is being offered at 34 LuCIN sites – institutions that are members of the Lupus Clinical Investigators Network managed by Lupus Therapeutics, an affiliate of the Lupus Research Alliance.

To Learn More Contact
Call UCB Cares +1844599 ext 2273 or UCBCares&ucb.com.
ClinicalTrials.gov identifier (NCT number):NCT04294667 

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A Study of Baricitinib (LY3009104) in Participants With Systemic Lupus Erythematosus (BRAVE I)

First filed August 2018, Updated Oct. 2020 - Active, Not Recruiting

CATEGORIES: General SLE

The reason for this randomized, double-blind, placebo-controlled, parallel-group, phase 3 study is to see how effective and safe the study drug known as baricitinib is in participants with systemic lupus erythematosus (SLE).

To Learn More Contact
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559
Mon – Fri 9 AM – 5 PM Eastern time (UTC/GMT – 5 hours, EST)Eli Lilly and Company
ClinicalTrials.gov identifier: NCT03616912

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Role of PPAR-y Anonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

First filed January 2015, updated Oct. 2020 - Completed

CATEGORIES: General SLE

This Phase 1/2 randomized study sponsored by the U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is looking at how well pioglitazone improves blood vessel function and decreases blood vessel inflammation for patients with lupus. The study is being conducted at the NIH Clinical Center in Bethesda, Maryland.

To Learn More Contact
Call 800-411-1222 ext or prpl@mail.cc.nih.gov
ClinicalTrials.gov identifier: NCT02338999

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A Phase 2a of RSLV-132 in Subjects With Systemic Lupus Erythematosus (SLE)

first filed January 2016, updated Oct. 2020 - Completed

CATEGORIES: General SLE

This study evaluates the impact of 13 bi-weekly intravenous infusions of RSLV-132 on the cutaneous manifestations in subjects with systemic lupus erythematosus. The trial is sponsored by Resolve Therapeutics.

To Learn More Contact
James Posada, Ph.D. at 208 727 7010 or jp@resolvebio.com
ClinicalTrials.gov identifier: NCT02660944

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