Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis (SELUNE)

CATEGORIES: Lupus Nephritis

The purpose of this trial is to evaluate the efficacy and safety of subcutaneous secukinumab 300 mg compared to placebo, in combination with standard of care therapy (SoC), in subjects with active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features).

To Learn More Contact
Novartis Pharmaceuticals at 1-888-669-6682 or by email at novartis.email@novartis.com
ClinicalTrials.gov identifier: NCT04181762

Dose Finding, Efficacy and Safety of BI 655064 in Patients With Active Lupus Nephritis

First filed May 2016, updated Aug. 2020 - Completed

CATEGORIES: Lupus Nephritis

The overall purpose of the study is to assess the efficacy of three different doses of BI 655064 against placebo as add-on therapy to standard of care (SOC) treatment for active lupus nephritis in order to characterize the dose-response relationship within the therapeutic range, and select the target dose for phase III development.

Study sponsor: Boehringer Ingelheim

To Learn More Contact
Boehringer Ingelheim Call Center at1-800-243-0127 or  clintriage.rdg@boehringer-ingelheim.com
ClinicalTrials.gov identifier: NCT02770170

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Dynamic Imaging of Variation in Lupus Nephritis (DIVINE)

First filed April 2017, updated July 2020 - Active, Not Recruiting

CATEGORIES: Lupus Nephritis

This multicenter trial is using a variety of kidney imaging tools, including magnetic resonance imaging to evaluate and monitor the kidneys of patients with lupus nephritis (LN) to determine if these non-invasive tools could replace surgical biopsy.

Study Status: Completed

To Learn More Contact
Rebecca Bender at 434-477-2675 or rebeccabender@ampel.org
ClinicalTrials.gov identifier: NCT03180021

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A Phase 2 Safety and Efficacy Study of Filgotinib and GS-9876 in Participants with Lupus Membranous Nephropathy (LMN)

First filed Sept. 2017, updated May 2020 - Completed

CATEGORIES: Lupus Nephritis

The purpose of thisPhase 3 study is assess the long-term safety and tolerability of voclosporin compared with placebo for up to an additional 24 months following completion of treatment in the AURORA 1 study in subjects with lupus nephritis (LN).

To Learn More Contact
GS-US-437-4093@gilead.com 
ClinicalTrials.gov identifier: NCT03285711

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Aurinia Renal Assessments 2: Aurinia Renal Response in Lupus With Voclosporin (AURORA2)

First filed July 2018, verified August 2020 - Active, Not Recruiting

CATEGORIES: Lupus Nephritis

The purpose of thisPhase 3 study is assess the long-term safety and tolerability of voclosporin compared with placebo for up to an additional 24 months following completion of treatment in the AURORA 1 study in subjects with lupus nephritis (LN).

To Learn More Contact
Antonia Coeshall at 441962715493 or acoeshall@auriniapharma.com
Laura Lisk at (0)7790555604 or llisk@auriniapharma.com
ClinicalTrials.gov identifier: NCT03597464

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